Establishing areas in which the domestic cat is a suitable role model for the cheetah, as well as when it is not, this work highlights where the cheetah is unique from the other cats and species-specific in its needs. Highlighting areas such as the ecological, anatomical, and physiological considerations, information is provided on nutrient requirement, metabolism, and reproduction comparisons to the domestic cat. The study is intended to be a useful text for zoo veterinarians, nutritionists, managers, and keepers alike, as well as being of interest to companion animal nutritionists and reproductive physiologists.